GLOBAL PROTEIN CONJUGATION BY UBIQUITIN-LIKE-MODIFIERS DURING ISCHEMIC STRESS IS REGULATED BY MICRORNAS AND CONFERS ROBUST TOLERANCE TO ISCHEMIA.

Global protein conjugation by ubiquitin-like-modifiers during ischemic stress is regulated by microRNAs and confers robust tolerance to ischemia.

Hibernation torpor provides an excellent model of natural tolerance to ischemia.We have previously shown that massive global SUMOylation occurs during hibernation torpor in ground squirrels.We have also shown that overexpression of Ubc9, SUMO-1, or SUMO-2/3 provides protection against ischemic damage in cell lines and cortical neurons exposed to ox

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Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits

Human genome-wide association studies (GWAS) have successfully identified thousands of susceptibility loci for common diseases with complex genetic etiologies.Although the susceptibility variants identified by GWAS usually have only modest effects on individual disease risk, they contribute to a substantial burden of trait variation in the overall

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With a little help from my friends: importance of protist-protist interactions in structuring marine protistan communities in the San Pedro Channel

ABSTRACT Marine protists form complex communities that are shaped by environmental and biological ecosystem properties, as well as ecological interactions between organisms.While all of these factors play a role in shaping protistan cabin still decanter communities, the specific ways in which these properties and interactions influence protistan co

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Case report: Reconstruction of the long-gap unilateral absence of right pulmonary artery with contralateral pulmonary artery flap and autologous pericardial graft

Unilateral absence of pulmonary artery (UAPA) is a rare type of congenital abnormality that may coexist with other congenital abnormalities or present as an isolated lesion, the latter form can be asymptomatic.Surgical procedure is chrysler 300 phantom grill usually carried out when UAPA was diagnosed with significant symptoms, and the aim of surge

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